Carnegie Mellon University
April 18, 2017

Thesis Defense: Theodore Roman

Monday, April 24th, 2017
GHC 7101


Understanding Tumor Composition and Evolution Through Geometric Models


Despite rapid progress in the understanding and treatment of disease over the course of the past 100 years, diagnosis and treatment of cancer has become a focal point for basic science research. As a result, advances have been made in quantifying the myriad changes in tumor genomes, transcriptomes, epigenomes, and metagenomes as compared to healthy tissue.  Specific to the work of this thesis, technical advances have led to more robust quantification of RNA expression states via RNA-seq, and DNA copy number quantification via DNA-seq. These approaches allow for the measurement of the state of tens of thousands of genes in a sample.  Moreover, the enhanced quantification has led to understanding the existence of heterogeneity among tumors.

Advisor: Russell Schwartz

Committee: Adrian Lee, Robin Lee, Jessica Zhang, Jian Ma

Ted Roman Thesis Defense 2017