Irene received her B.S. in Mathematics with a minor in Biology from the Massachusetts Institute of Technology in 2010. There, she began her career as a computational biologist while doing research with Bonnie Berger. She then went to graduate school at Stanford University, where she received her Ph.D. in Computer Science in 2017. At Stanford, she worked in Hunter Fraser and Anshul Kundaje's labs to develop methods to analyze novel high-throughput sequencing datasets to better understand the roles of DNA methylation and Cys2-His2 zinc finger transcription factor binding in transcriptional regulation. After graduate school, she worked as a Lane Postdoctoral Fellow in Andreas Pfenning's lab in the Computational Biology Department at Carnegie Mellon University, where she developed methods to identify regulatory elements whose regulatory activity differences between species are associated with the evolution of neurological phenotypes. In fall 2024, she will be starting her own lab in the Departments of Biological Sciences and Computational Biology at Carnegie Mellon University, where she will be extending her methods to metabolic phenotypes and dissecting the sequence differences at regulatory element orthologs that have caused regulatory activity differences between species.