Irene Kaplow
Assistant Professor, Department of Biological Sciences and Ray and Stephanie Lane Computational Biology Department
Address:
Ray and Stephanie Lane Computational Biology Department, SCSCarnegie Mellon University
5000 Forbes Avenue
Pittsburgh, PA 15213
Gates-Hillman Center 7511
Administrative Assistant: Erin Driskill
Andrew Bellesis
Lab Manager
Mary Ma
Postdoctoral Fellow
Irene Kaplow is an Assistant Professor in the Departments of Biological Sciences and Computational Biology at Carnegie Mellon University. Her lab investigates the role of changes in transcriptional regulation in the evolution of vertebrate metabolic phenotypes and dissects the sequence differences at regulatory element orthologs that have caused regulatory activity differences between species. Irene received her B.S. in Mathematics with a minor in Biology from the Massachusetts Institute of Technology in 2010. There, she began her career as a computational biologist while doing research with Bonnie Berger. She next went to graduate school at Stanford University, where she received her Ph.D. in Computer Science in 2017. At Stanford, she worked in Hunter Fraser and Anshul Kundaje's labs to develop methods to analyze novel high-throughput sequencing datasets to better understand the roles of DNA methylation and Cys2-His2 zinc finger transcription factor binding in transcriptional regulation. She then worked as a Lane Postdoctoral Fellow in Andreas Pfenning's lab in the Computational Biology Department at Carnegie Mellon University, where she developed methods to identify regulatory elements whose regulatory activity differences between species are associated with the evolution of neurological phenotypes. After that, she worked as a research scientist in Charles Gersbach's lab in the Center for Advanced Genomics Technologies at Duke University, where she helped experimentally test the effects of manipulating a candidate myosin gene enhancer on myosin gene expression and cardiomyocyte development.